Utility of Bispectral Index Monitoring for Diagnosis and Assessment of Severity of Overt and Minimal Hepatic Encephalopathy Before and After Treatment in Patients with Cirrhosis

Abstract

Background and Aims: Severity of hepatic encephalopathy (HE) is graded using West Haven criteria and psychometric tests. There is no gold standard for grading HE and monitoring its progression. We evaluated utility of bispectral index (BIS) to diagnose overt and minimal HE (MHE), grade HE and monitor improvement or worsening of overt and MHE with treatment.