Abstract
SummaryWhen tested for ability to delay estrus in female dogs. 17α-acetoxyprogesterone successfully inhibited estrus during 70-wk treatment period. When incorporated in dog feed and fed ad lib., a minimum dose of 2.5 mg kg was effective. When administered once daily in suspension form a dose of 4 mg kg was required. Histopathological examination of ovaries of treated dogs revealed inhibition of development of vesicular follicles. Bitches previously treated with 17α-acetoxyprogesterone returned to cycle, were bred and whelped normal, healthy litters of puppies. It was suggested that bitches be bred no sooner than 6 mos after cessation of treatment to insure maximum fertility. Drug was judged completely safe for dogs.The author is indebted to members of Depts. of Pathology and Endocrinology. The advice of Drs. R. L. Johnston, R. A. Runnells, and R. O. Stafford. The Upjohn Co., and Dr. R. K. Meyer, Univ. of Wisconsin, is gratefully akcnowledged.
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