Abstract
PurposeThis study attempted to estimate the utility weights for hypothetical chronic obstructive pulmonary disease (COPD) health states, including the effect of exacerbation, and based on utilities elicited from a representative sample using the time trade-off (TTO).MethodsA total of 200 study subjects were recruited using a quota sampling method in Seoul, Korea. Ten COPD health profiles were described reflecting the severity of COPD and the extent of exacerbation. Respondents evaluated each health state using a visual analogue scale and TTO during a personal interview. TTO values were estimated using a linear mixed model, and the model performance was evaluated in terms of its predictive ability and goodness of fit.ResultsThe estimated TTO values were 0.824 in moderate, 0.646 in severe, and 0.305 in very severe COPD health states. The estimated utility decrements in TTO varied from 0.082 for a non-serious exacerbation to 0.228 for one non-serious plus one serious exacerbation per year. The mean absolute error of the TTO model was 0.008, and the generalized R2 was 0.86.ConclusionThe social preference of various COPD health states and the utility decrement due to exacerbation can be useful for the economic evaluation of COPD intervention in Korea.Electronic supplementary materialThe online version of this article (doi:10.1186/s12955-015-0228-2) contains supplementary material, which is available to authorized users.
Highlights
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation which is usually progressive and associated with an enhanced chronic inflammatory response in the airway and lung to noxious particles or gases
Evidence suggests that the EQ-5D for COPD and its exacerbations has limited discriminatory ability, between moderate and severe COPD, and that the responsiveness to clinically relevant changes in stable COPD over time, due to treatment, appears limited [11,12,13]
Health professionals involved in the care of COPD patients were interviewed regarding the same evaluation task
Summary
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation which is usually progressive and associated with an enhanced chronic inflammatory response in the airway and lung to noxious particles or gases. Evidence suggests that the EQ-5D for COPD and its exacerbations has limited discriminatory ability, between moderate and severe COPD, and that the responsiveness to clinically relevant changes in stable COPD over time, due to treatment, appears limited [11,12,13]. This utility may differ according to the perspective or type of interviewee, such as patients, physicians or the general population [14]
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