Abstract
Cyanothioformamides were reacted with benzoyl hydrazine, acetyl hydrazine and anthranilic acid to afford oxadiazole (4), triazolthione (5) and benzothiazoloquinazolinone derivatives (6) respectively. They also reacted with thiocarbohydrazide, semicarbazide, thiosemicarbazide and active methylene compounds to produce 3-hydrazino-1,2-,4-triazol-5-thione (8), thiocarbamoylsemicarbazide (9), triazolidinedithione (10). Treatment of imidazolidine iminothiones with different nucleophilic reagents gave imidazotriazines besides other imidazolidine derivatives. Some of the newly synthestized derivatives were screened for antibacterial and antifungal activity and showed prononced antimicrobial activity.
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