Abstract
Uticaj različitih formulacija takrolimusa na dozni režim i izloženost leka tokom prve godine nakon transplantacije bubrega
Highlights
Kidney transplantation (Tx) is the best treatment option for patients with end-stage renal disease (ESRD), whereby successful Tx provides better quality of life and longer survival compared to dialysis [1]
The mean values of AST, ALT, GLU, ALB and Blood Urea Nitrogen (BUN) were within physiological range, while the values of CRE and estimated glomerular filtration rate (eGFR) indicated the satisfactory function of the transplanted organ for the observed post-transplant period
Patients on Tac-OD preparation were receiving higher daily doses of Tac compared to patients on Tac-TD preparation after the third-month post-transplant
Summary
Kidney transplantation (Tx) is the best treatment option for patients with end-stage renal disease (ESRD), whereby successful Tx provides better quality of life and longer survival compared to dialysis [1]. Immunosuppressive drugs are used to suppress immune response by preventing acute rejection in the early period after Tx and providing long-term survival of the transplanted organ [2]. Tacrolimus is the background of the most immunosuppressive protocols after Tx worldwide, whereas its clinical use is characterized by marked interindividual variability in its pharmacokinetics, narrow therapeutic index and chronic nephrotoxicity [5,6]. Investigation of factors contributing to pharmacokinetic variability and application of TDM seems to be more important considering that target therapeutic range of Tac is even narrower than optimal range and dependent to period after Tx. In the present study, Tac concentrations were maintained in target range of 8–12 ng/mL for the first 90 days and 6–10 ng/mL afterwards
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
