Abstract
IntroductionUterine tumors resembling ovarian sex cord tumors (UTROSCT) are uterine neoplasms of unknown histiogenesis which show near complete differentiation towards ovarian sex cord elements and are postulated to arise from pluripotential uterine mesenchymal cells or endometrial stromal cells with secondary sex cord differentiation.Case presentationA 48 year old post-menopausal women presented with abnormal uterine bleeding for which she underwent total abdominal hysterectomy with bilateral salpingo-ophorectomy. Gross examination revealed a gelatinous grayish white tumor confined to the myometrium, 7 cm in maximum dimention. Microscopic examination revealed monomorphic round to oval tumor cells in anastomosing cords and trabeculae with myxoid background. Immunohistochemically, tumor cells showed diffuse positivity for vimentin, CD99 and S100, while focal positivity was seen with pancytokeratin immunostain. The case was diagnosed as UTROSCT. No evidence of metastasis was found on systemic clinical and radiologic workup.ConclusionUTROSCT are rare uterine tumors which can be diagnosed with certainty on morphologic and immunohistochemical grounds. It is important to recognize these tumors as they behave differently from endometrial stromal tumors with sex cord like elements (ESTSCLE).
Highlights
Uterine tumors resembling ovarian sex cord tumors (UTROSCT) are uterine neoplasms of unknown histiogenesis which show near complete differentiation towards ovarian sex cord elements and are postulated to arise from pluripotential uterine mesenchymal cells or endometrial stromal cells with secondary sex cord differentiation.Case presentation: A 48 year old post-menopausal women presented with abnormal uterine bleeding for which she underwent total abdominal hysterectomy with bilateral salpingo-ophorectomy
UTROSCT are rare uterine tumors which can be diagnosed with certainty on morphologic and immunohistochemical grounds
Heterologous mesodermal tumors of the uterus first came to clinical attention when Morehead and Bowman described a case of a uterine neoplasm resembling granulosa cell tumor in 1945 [1]
Summary
UTROSCT are uterine tumors of unknown histiogenesis They display a variety of architectural patterns and expresses wide range of expression for epithelial, stromal and sex cord markers. Consent Written informed consent was obtained from the patient for publication of this Case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Ethics committee of Liaquat National hospital approved the study. Authors’ contributions AAA: main author of manuscript, have made substantial contributions to conception and design of data. MME: main author of manuscript and have been involved in drafting and revision of the manuscript. All authors read and approved the final manuscript. Author details 1Department of Histopathology, Liaquat National Hospital and Medical College, Karachi, Pakistan. Author details 1Department of Histopathology, Liaquat National Hospital and Medical College, Karachi, Pakistan. 2Liaquat National Hospital and Medical College, Karachi, Pakistan. 3Dhaka Medical College, Dhaka, Bangladesh
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