Abstract
The histamine changes accompanying the growth of decidual tissue were differentiated from the histamine changes occurring as a result of the injury used to elicit this growth. Histamine concentration decreased about 50% in decidual tissue when compared with unstimulated uteri, but total histamine content was elevated in deciduomata, being about 100 % higher than in control horns. The procedure utilized to elicit the decidual reaction consisted of cutting the uterus and then scratching it. The cut increased histamine concentration about 100 %, while the endometrial scratch caused only a slight decrease in histamine concentration. It thus appears that the response to the injury and inflammation involved in producing the decidual reaction was an increase in histamine concentration, while the decidual growth response resulted in a decrease in histamine concentration.
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