Abstract
Leiomyomas, commonly known as fibroids, are the most common smooth muscle overgrowth in women and a major indication for hysterectomy. The molecular mechanisms of leiomyomas remain largely unknown. Leiomyomas show increased cell proliferation as compared to myometrium. The use of antioxidant strategies is thought to be beneficial in treatment of fibroids. The objective of this study is to determine the differential expression levels of superoxide dismutase (SOD3) and catalase (CAT), as well as the effect of hypoxia, in human leiomyoma versus myometrium cells.
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