Abstract
It has elsewhere been shown that estrogenic stimulation alters the histologic structure of the cervical squamocolumnar junction in mice. In order to determine if similar estrogen-controlled changes take place in the human, sections of cervix were examined from fetuses stimulated by maternal estrogen, and from nonstimulated immature females. Two types of junction were observed, being associated respectively with cervices showing positive and negative evidence of estrogenic stimulation. Certain histologic appearances were observed which are usually regarded as evidence that squamous metaplasia is in progress, and their existence was inversely correlated with evidence of estrogenic stimulation. It was concluded that the histologic character of the human squamocolumnar junction is determined by the level of estrogenic stimulation and that the histologic evidence usually advanced in favor of metaplasia is in fact open to more than one interpretation.
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