Abstract
The effects of intrauterine application of actinomycin D and calf thymus histones on the akaline phosphatase activity and histological changes of the uteri of castrated rats stimulated with 17β-estradiol were studied. The uterine phosphatase activity induced with 17β-estradiol was suppressed nearly to the level of castrated rats at high doses of actinomycin D (6 μg/horn). Although the epithelial cells were completely denuded, histochemical localization of phosphatase activity was demonstrated in the blood vessels, glandular epithelium and stroma. Lower doses of actinomycin D inhibited the height of the epithelial cells induced by 17β- estradiol and an unexplained rise in the phosphatase activity above the control level was observed. Calf thymus histones administered into the uterine cavity incited an acute inflammatory reaction and did not inhibit the increase in uterine alkaline phosphatase induced by 17β- estradiol. (Endocrinology 82: 1069, 1968)
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