Uterin seröz karsinom ve uterin berrak hücreli karsinom tanısı alan hastalarda klinikopatolojik özelliklerin ve sağ kalım sonuçlarının karşılaştırılması

Abstract

AbstractAim: We aimed to compare the clinicopathological characteristics and survivals between uterine serous carcinoma (USC) and uterine clear cell carcinoma (UCCC).Materials and Methods: The study population consists of women who were diagnosed with USC and UCCC according to the final pathology reports. Demographic, clinicopathological and survival data were collected and analyzed.Results: A total of 69 patients with USC and 36 patients with UCCC were included in the final analysis. Patients in the USC group tend to have more advanced stage disease compared to the patients in the UCCC group and this was statistically significant between the groups (61.1% vs 36.2%, respectively; p=0.015). Patients with USC were more likely to have omental metastasis (17/69 vs 2/36, p=0.016) and positive peritoneal cytology (25/69 vs 5/36, p=0.016). In the multivariate analysis, only positive peritoneal cytology remained as an independent prognostic factor for decreased disease free survival (DFS) for the entire cohort (HR 5.07, 95% CI 2.07-12.42; p<0.001). Only positive peritoneal cytology was an independent prognostic factor for decreased overall survival (OS) for the entire cohort (HR 3.50, 95% CI 1.31-9.33; p=0.012) in the multivariate analysis.Conclusion: We concluded that positive peritoneal cytology was an independent prognostic factor for both DFS and OS in patients with USC and UCCC in the current study. Because of the high rate of omental metastasis in the USC group, we also suggest performing an omentectomy as a part of the comprehensive surgical staging surgery.