Ustekinumab in Real-Life Practice: Experience in 116 Patients with Moderate-To-Severe Psoriasis.

Abstract

Ustekinumab is a monoclonal antibody directed against the p40 subunit common to both IL-12 and IL-23 cytokines.Although the evidence of ustekinumab efficacy and safety in clinical trials is extensively recognized, data on its use in clinical practice islimited. Our objective is to report on the real-life experience of two Portuguese dermatology departments with ustekinumab in patientswith moderate to severe psoriasis, and to identify the clinical characteristics associated with a weaker clinical response. Clinical, demographic, and therapeutic response data was retrospectively collected in 116 patients withmoderate to severe psoriasis treated with ustekinumab between November 2009 and December 2015. A PASI75 therapeutic response was observed in 67.2%, 85.3%, 89.6% and 88.7% of patients at weeks 4, 12, 24 and 52,respectively. Ustekinumab was discontinued in seven patients (three due to primary failure, three due to secondary treatment failure,and one due to adverse events). Neither cardiovascular events nor cases of reactivation of previous infections (tuberculosis, hepatitisB) were observed during follow-up. In nine patients methotrexate was used as adjuvant therapy, and fourteen patients requiredustekinumab dosage optimization. No side effects were observed in the two latter groups. The therapeutic response was higher inpatients naïve to biologic therapies as compared to non-naïve patients. A trend towards lower clinical response was observed in patients weighing between 90-100 kg, anddosage optimization in this group of patients may be of value prior to considering biologic switch.