Abstract
Existing work indicates that the degree of variation of somatosensory evoked potential (SEP) signals between a healthy spinal pathway and spinal pathway affected by spinal cord injury (SCI) can be used to evaluate the integrity of the spinal pathway. This paper develops a metric that exploits the time-domain features of SEP signals (relative amplitude, time scaling, and time duration) in order to quantify the level of SCI. The proposed method is tested on actual SEP signals collected from rodents afflicted with focal demyelination SCI. Results indicate that the proposed method provides a robust assessment of the different degrees of demyelination in the spinal cord.
Highlights
The spinal cord provides a transmission pathway for motor and sensory signals between the central and peripheral nervous systems [1]
Existing work indicates that the degree of variation of somatosensory evoked potential (SEP) signals between a healthy spinal pathway and spinal pathway affected by spinal cord injury (SCI) can be used to evaluate the integrity of the spinal pathway
This paper develops a metric that exploits the time-domain features of SEP signals in order to quantify the level of SCI
Summary
The spinal cord provides a transmission pathway for motor and sensory signals between the central and peripheral nervous systems [1]. Somatosensory evoked potentials (SEP), which are cortical signals recorded in response to sensory stimulation, are obtained by electrical stimulation of the median nerve at the wrist or the posterior tibial nerve at the ankle [7] This technique can be used to monitor the ongoing neurophysiological changes during the recovery period after SCI. Previous work [10,11,12] has been done to develop metrics for quantifying the level of SCI by comparing the variation between SEP signals. Parameters relating the time-domain variation between SEP signals collected on rodents are used to evaluate the level of SCI.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
