Abstract

The Clinical and Translational Science Awards (CTSA) program of the National Center for Advancing Translational Sciences (NCATS) seeks to improve population health by accelerating the translation of scientific discoveries in the laboratory and clinic into practices for the community. CTSAs achieve this goal, in part, through their pilot project programs that fund promising early career investigators and innovative early-stage research projects across the translational research spectrum. However, there have been few reports on individual pilot projects and their impacts on the investigators who receive them and no studies on the long-term impact and outcomes of pilot projects. The Georgia CTSA funded 183 pilot projects from 2007 to 2015. We used a structured evaluation framework, the payback framework, to document the outcomes of 16 purposefully-selected pilot projects supported by the Georgia CTSA. We used a case study approach including bibliometric analyses of publications associated with the selected projects, document review, and investigator interviews. These pilot projects had positive impact based on outcomes in five "payback categories": (1) knowledge; (2) research targeting, capacity building, and absorption; (3) policy and product development; (4) health benefits; and (5) broader economic benefits. Results could inform our understanding of the diversity and breadth of outcomes resulting from Georgia CTSA-supported research and provide a framework for evaluating long-term pilot project outcomes across CTSAs.

Highlights

  • The Clinical and Translational Science Awards (CTSA) program of the National Center for Advancing Translational Sciences (NCATS) seeks to improve population health by accelerating the translation of scientific discoveries in the laboratory and clinic into practices for the community

  • Every individual CTSA center, or “hub”, across the nation has a pilot project program aimed at funding promising early career investigators and innovative early-stage research projects across the translational research spectrum

  • Among the overall set of 358 pilot project grants awarded by the Georgia CTSA from 2007 to 2020, 43% of grantees were female, at least 11% were from under-represented groups, and the majority were assistant (46%) or associate professors (21%)

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Summary

Introduction

The Clinical and Translational Science Awards (CTSA) program of the National Center for Advancing Translational Sciences (NCATS) seeks to improve population health by accelerating the translation of scientific discoveries in the laboratory and clinic into practices for the community. Conclusions: Results could inform our understanding of the diversity and breadth of outcomes resulting from Georgia CTSA-supported research and provide a framework for evaluating long-term pilot project outcomes across CTSAs. One of the primary goals of the Clinical and Translational Science Awards (CTSA) program of the National Center for Advancing Translational Sciences (NCATS) is to improve population health by accelerating the translation of scientific discoveries in the laboratory and clinic into practices for the community [1]. One of the primary goals of the Clinical and Translational Science Awards (CTSA) program of the National Center for Advancing Translational Sciences (NCATS) is to improve population health by accelerating the translation of scientific discoveries in the laboratory and clinic into practices for the community [1] To achieve this goal, every individual CTSA center, or “hub”, across the nation has a pilot project program aimed at funding promising early career investigators and innovative early-stage research projects across the translational research spectrum. The Georgia CTSA awards an average of 27 pilot project grants per year

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