Abstract

BackgroundTimely information about disease severity can be central to the detection and management of outbreaks of acute respiratory infections (ARI), including influenza. We asked if two resources: 1) free text, and 2) structured data from an electronic medical record (EMR) could complement each other to identify patients with pneumonia, an ARI severity landmark.MethodsA manual EMR review of 2747 outpatient ARI visits with associated chest imaging identified x-ray reports that could support the diagnosis of pneumonia (kappa score = 0.88 (95% CI 0.82∶0.93)), along with attendant cases with Possible Pneumonia (adds either cough, sputum, fever/chills/night sweats, dyspnea or pleuritic chest pain) or with Pneumonia-in-Plan (adds pneumonia stated as a likely diagnosis by the provider). The x-ray reports served as a reference to develop a text classifier using machine-learning software that did not require custom coding. To identify pneumonia cases, the classifier was combined with EMR-based structured data and with text analyses aimed at ARI symptoms in clinical notes.Results370 reference cases with Possible Pneumonia and 250 with Pneumonia-in-Plan were identified. The x-ray report text classifier increased the positive predictive value of otherwise identical EMR-based case-detection algorithms by 20–70%, while retaining sensitivities of 58–75%. These performance gains were independent of the case definitions and of whether patients were admitted to the hospital or sent home. Text analyses seeking ARI symptoms in clinical notes did not add further value.ConclusionSpecialized software development is not required for automated text analyses to help identify pneumonia patients. These results begin to map an efficient, replicable strategy through which EMR data can be used to stratify ARI severity.

Highlights

  • Effective responses to epidemics of infectious diseases hinge on early outbreak detection, and on an ongoing assessment of disease severity

  • For surveillance systems aimed at epidemics of acute respiratory infections (ARI), the rationale for incorporating information about disease severity is compelling: 1) doing so could help discover outbreaks that involve only a small number of very sick patients, such as what initially occurred with SARS [1] or what could be anticipated shortly after a criminal release of plague [2] or tularemia [3]; 2) such systems could help adjust ongoing responses to seasonal or pandemic influenza, where severity can vary by orders of magnitude between epidemics [4] or even between waves of the same epidemic [5,6]

  • We asked how information retrieved from the free-text of chest imaging reports and clinical notes could complement structured data to uncover pneumonia cases

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Summary

Introduction

Effective responses to epidemics of infectious diseases hinge on early outbreak detection, and on an ongoing assessment of disease severity. For surveillance systems aimed at epidemics of acute respiratory infections (ARI), the rationale for incorporating information about disease severity is compelling: 1) doing so could help discover outbreaks that involve only a small number of very sick patients, such as what initially occurred with SARS [1] or what could be anticipated shortly after a criminal release of plague [2] or tularemia [3]; 2) such systems could help adjust ongoing responses to seasonal or pandemic influenza, where severity can vary by orders of magnitude between epidemics [4] or even between waves of the same epidemic [5,6]. Information about disease severity can be central to the detection and management of outbreaks of acute respiratory infections (ARI), including influenza. We asked if two resources: 1) free text, and 2) structured data from an electronic medical record (EMR) could complement each other to identify patients with pneumonia, an ARI severity landmark

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