Abstract
Hip shape is an important determinant of hip osteoarthritis and osteoporotic hip fracture; however, little is known about its development in childhood and adolescence. While previous studies largely focused on individual geometrical indices of hip geometry such as neck-shaft angle or femoral neck width, statistical shape modelling offers the means to quantify the entire contour of the proximal femur, including lesser trochanter and acetabular eyebrow. We describe the derivation of independent modes of variation (hip shape mode scores) to characterise variation in hip shape from dual-energy X-ray absorptiometry (DXA) images in the Avon Longitudinal Study of Parents and Children (ALSPAC) offspring, using statistical shape modelling. ALSPAC is a rich source of phenotypic and genotypic data which provides a unique opportunity to investigate the environmental and genetic influences on hip shape in adolescence, as well as comparison with adult hip shape.
Highlights
Osteoarthritis (OA) and osteoporotic fractures are the most common age-related musculoskeletal diseases and are associated with significant healthcare burden
Previous studies suggest that hip shape is an important risk factor for both hip OA1,2 and osteoporotic hip fracture[3]
Statistical shape modelling is a method which uses a set of landmark points to describe an outline of an object
Summary
Osteoarthritis (OA) and osteoporotic fractures are the most common age-related musculoskeletal diseases and are associated with significant healthcare burden. Previous studies suggest that hip shape is an important risk factor for both hip OA1,2 and osteoporotic hip fracture[3]. Hip shape architecture has been assessed by measuring lengths and angles. Statistical shape modelling is a method which uses a set of landmark points to describe an outline of an object. It provides the means for capturing global shape of an object as opposed to a single geometrical measurement and can represent a combination of several different aspects of proximal femur shape (e.g. variation in femoral neck (FN) along with variation in femoral head)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
