Using silver poly (acrylate) matrix (Haemoblock) in children with lymphatic malformations

Abstract

Abstract Lymphatic malformations (LM) are a congenital malformation of lymphatic vessels. There exist large, small and mixed cystic LMs. Up to the present day, the causes of LM remain the subject of scientific research. Special sclerosing agents such as Doxycycline, Bleocyne, Picibanil (OK-432) and other drugs are used for sclerosing of LM. Due to the special characteristics of the impact of each drug on the endothelium, during the early post-surgical period there occur various undesirable effects (swelling, pain conditions, toxic effects, allergies, etc.), moreover, the effectiveness of the used sclerosing agents is not always sufficient to obtain a good clinical effect. The goal of our work is to evaluate the use of the Haemoblock™ sclerotherapy in children with various forms of lymphatic malformations. We carried out a retrospective analysis of the use of the silver poly (acrylate) matrix (Haemoblock™) for sclerotherapy (off-label protocol) of various forms of LM in children who underwent treatment at the Center for Vascular Pathology (Moscow) during the period from 2016 to 2018. After the conducted surgery - sclerotherapy with the Haemoblock™ in children with various LMs, we obtained the following results: excellent and good - in 6 cases, satisfactory - in 2 cases, no negative result was obtained. In the Center for Vascular Pathology (Moscow) in 2016–2018, there was conducted a treatment of 8 children with LM of various types and localization. During the early post-surgical stages (1–3 h after surgery), 4 children showed severe pain syndrome, which stopped on its own without prescription of drug-induced pain killers. 12–24 h after sclerotherapy, 6 children also showed an increase in swelling in the area of the surgery. The swelling persisted for 3–6 days, and stopped on its own. Considering the positive results of treatment, further multi center study of the use of the Haemoblock™ is needed for the purpose of the LM sclerotherapy in children.