Using ROC analysis to confirm an algorithmically established diagnosis of lichen planus

Abstract

The use of ROC analysis allowed the authors to determine cytogenetic criteria to confirm the diagnosis of lichen planus, obtained by selecting the most informative features and interpreting the micronucleus test in buccal epithelium, calculating their critical values, sensitivity and specificity for use as diagnostic tests. An increase in the number of cells with micronuclei in the lesion of lichen planus is a sign of genetic instability, which can trigger the process of their malignancy. Recognition of nuclear aberrations against the background of nuclear destruction makes it possible to diagnose lichen planus in patients).