USING RESULTS OF FIRST-TRIMESTER BIOCHEMICAL SCREENING AND UTERINE ARTERY PULSATILITY INDEX FOR INCLUSION IN RISK GROUPS FOR FETAL GROWTH RESTRICTION

Abstract

Objective: to study the combined use of first-trimester biochemical screening results and uterine artery pulsality index (PI) for inclusion in risk group for fetal growth restriction (FGR), improvement of pregnancy outcomes in women from the risk group for the development of FGR.Material and methods. The work is based on the results of studies conducted from 2009 to 2014 in the maternity unit of Republican Clinical Hospital № 2 MoH in the Republic of Tatarstan which is the clinical facility for the Department of Obstetrics and Gynecology № 1 of the Continuing Medical Education Institution “Kazan State Medical University” MoH RF, and maternity unit and prenatal clinic of the Volzhskaya Central City Hospital in the Mari El Republic. First-trimester biochemical screening results and uterine artery PI were the basis for the formation of FGR risk groups. Pregnancy and delivery outcomes in 156 pregnant women with a risk for the development of FGR and in 25 healthy controls were evaluated. In order to improve the placental blood flow based on the proven safety profile, all women with FGR received dipyridamole in the II trimester of pregnancy for at least 3 weeks.Conclusion: concomitant decrease in PAPP-A MoM and increase in uterine artery PI provide the most valuable information for forecasting FGR. Administration of dipyridamole by women with FGR helps to improve placental blood flow, prevents degenerative changes in the placenta, and promotes live births even in III degree FGR.