USING REAL-WORLD DATA TO IDENTIFY THE PREVALENCE OF HEART DISEASE IN PATIENTS WITH CYSTIC FIBROSIS

Abstract

SESSION TITLE: Genetic and Autoimmune DisordersSESSION TYPE: Rapid Fire Original InvPRESENTED ON: 10/17/2022 12:15 pm - 1:15 pmPURPOSE: Cystic fibrosis (CF) is an autosomal recessive disease which is caused by mutations in the conductance regulator (CFTR) gene. It is a disease which primarily affects the respiratory, endocrine, reproductive, and gastrointestinal system. There is limited information on the impact of CF on the cardiovascular system.CF might affect the cardiovascular system directly by CFTR gene dysfunction in the heart and coronary arteries and indirectly with related conditions such as hypoxia, chronic inflammation, CF related diabetes, and pulmonary hypertension. Chronic inflammation, diabetes, and CFTR dysfunction in the vascular endothelium might lead to coronary artery disease. Hypoxia, electrolyte (chloride and bicarbonate) transport alterations could lead to arrhythmias.We aimed to identify the prevalence of cardiac complications, including heart failure (HF), acute myocardial infarction (AMI), and arrhythmias in patients with CF.METHODS: We identified patients with CF that were 18 years old or older by using the TriNetX research database which provides information from electronic medical records from several health care institutions primarily based in the United States. We analyzed the research network database From January 1, 2016, to December 31, 2021, and calculated prevalence as well as 5-year incidence of heart disease.RESULTS: A total of 17,070 patients were included in our study. 54% of the patients were females. The most prevalent cardiovascular disorders diagnosed in this cohort where heart failure [prevalence 11.338% (1921), incidence 8.542% (1403)], atrial fibrillation [prevalence (7.437% /1260), incidence (5.729% /953)], acute myocardial infarction prevalence [(3.813%/646), incidence (3.15% /530)], and supraventricular tachycardia prevalence [(3.76% /637), incidence (3.206% /540)], these were followed by atrial flutter [prevalence (2.16% /366), incidence (1.754%/296)], and ventricular tachycardia [prevalence (1.771% /300), incidence (1.369% /231)].Overall, males had higher incidence and prevalence in all outcomes except for supraventricular tachycardia 3.944% vs 3.548% and 3.371% vs 3.016% for incidence and prevalence respectively.CONCLUSIONS: CF patients have a high incidence and prevalence of heart failure, acute myocardial infarction, and arrhythmias.CLINICAL IMPLICATIONS: When compared to studies done in the general population, heart failure and arrhythmias appear to be higher in patients with CF. AMI appears to have a similar prevalence to the general population.DISCLOSURES: No relevant relationships by Kunal BhutaNo relevant relationships by Debanik ChaudhuriNo relevant relationships by Andres Cordova SanchezNo relevant relationships by Subash Nepal SESSION TITLE: Genetic and Autoimmune Disorders SESSION TYPE: Rapid Fire Original Inv PRESENTED ON: 10/17/2022 12:15 pm - 1:15 pm PURPOSE: Cystic fibrosis (CF) is an autosomal recessive disease which is caused by mutations in the conductance regulator (CFTR) gene. It is a disease which primarily affects the respiratory, endocrine, reproductive, and gastrointestinal system. There is limited information on the impact of CF on the cardiovascular system. CF might affect the cardiovascular system directly by CFTR gene dysfunction in the heart and coronary arteries and indirectly with related conditions such as hypoxia, chronic inflammation, CF related diabetes, and pulmonary hypertension. Chronic inflammation, diabetes, and CFTR dysfunction in the vascular endothelium might lead to coronary artery disease. Hypoxia, electrolyte (chloride and bicarbonate) transport alterations could lead to arrhythmias. We aimed to identify the prevalence of cardiac complications, including heart failure (HF), acute myocardial infarction (AMI), and arrhythmias in patients with CF. METHODS: We identified patients with CF that were 18 years old or older by using the TriNetX research database which provides information from electronic medical records from several health care institutions primarily based in the United States. We analyzed the research network database From January 1, 2016, to December 31, 2021, and calculated prevalence as well as 5-year incidence of heart disease. RESULTS: A total of 17,070 patients were included in our study. 54% of the patients were females. The most prevalent cardiovascular disorders diagnosed in this cohort where heart failure [prevalence 11.338% (1921), incidence 8.542% (1403)], atrial fibrillation [prevalence (7.437% /1260), incidence (5.729% /953)], acute myocardial infarction prevalence [(3.813%/646), incidence (3.15% /530)], and supraventricular tachycardia prevalence [(3.76% /637), incidence (3.206% /540)], these were followed by atrial flutter [prevalence (2.16% /366), incidence (1.754%/296)], and ventricular tachycardia [prevalence (1.771% /300), incidence (1.369% /231)]. Overall, males had higher incidence and prevalence in all outcomes except for supraventricular tachycardia 3.944% vs 3.548% and 3.371% vs 3.016% for incidence and prevalence respectively. CONCLUSIONS: CF patients have a high incidence and prevalence of heart failure, acute myocardial infarction, and arrhythmias. CLINICAL IMPLICATIONS: When compared to studies done in the general population, heart failure and arrhythmias appear to be higher in patients with CF. AMI appears to have a similar prevalence to the general population. DISCLOSURES: No relevant relationships by Kunal Bhuta No relevant relationships by Debanik Chaudhuri No relevant relationships by Andres Cordova Sanchez No relevant relationships by Subash Nepal