Abstract
Ca2+-activated K+ currents (IKCa) play a crucial role in cellular excitability. In some species, Ca2+-activated K+ currents play a role in cardiac repolarization and automaticity whereas in neurons, Ca2+-activated K+ currents underlie action potential after-hyperpolarization. Dynamic clamp enables us to electronically express ion channels, using mathematical models. However, modelling channels like IKCa requires measurement of real-time intracellular [Ca2+]. We combined a specialized low latency optical detector to measure [Ca2+] which was then used as input to drive the electronic expression of a modelled linear IKCa in dynamic clamp.
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