Abstract
Plasma concentrations of many cardiovascular and inflammatory proteins are altered after ST-elevation myocardial infarction (STEMI) and may provide prognostic information. We conducted a large-scale proteomic analysis in patients with STEMI, correlating protein levels to infarct size and left ventricular ejection fraction (LVEF) determined with cardiac magnetic resonance imaging. We analysed 131 cardiovascular and inflammatory proteins using a multiplex proximity extension assay and blood samples obtained at baseline, 6, 24, and 96 h from the randomised clinical trial CHILL-MI. Cardiac magnetic resonance imaging data at 4 ± 2 days and 6 months were available as per trial protocol. Using a linear regression model with bootstrap resampling and false discovery rate adjustment we identified five proteins (ST2, interleukin-6, pentraxin-3, interleukin-10, renin, and myoglobin) with elevated values corresponding to larger infarct size or worse LVEF and four proteins (TNF-related apoptosis-inducing ligand, TNF-related activation induced cytokine, interleukin-16, and cystatin B) with values inversely related to LVEF and infarct size, concluding that among 131 circulating inflammatory and cardiovascular proteins in the acute and sub-acute phase of STEMI, nine showed a relationship with infarct size and LVEF post-STEMI, with IL-6 and ST2 exhibiting the strongest association.
Highlights
Plasma concentrations of many cardiovascular and inflammatory proteins are altered after ST-elevation myocardial infarction (STEMI) and may provide prognostic information
The objective of this study was to perform a large-scale proteomic analysis using a novel proximity extension assay (PEA) to evaluate the hypothesis that plasma concentrations of 157 inflammation- and cardiovascularassociated proteins correlate to infarct size and ejection fraction in the acute and chronic phase post-STEMI as assessed by cardiac magnetic resonance imaging (CMR)
The primary endpoint in CHILL-MI was infarct size/myocardium at risk assessed by CMR on day 4 ± 2, which was not significantly reduced by hypothermia and all patients were followed-up with a second CMR after 6 months
Summary
Plasma concentrations of many cardiovascular and inflammatory proteins are altered after ST-elevation myocardial infarction (STEMI) and may provide prognostic information. The influence of inflammation in myocardial infarction extends beyond chronic inflammation, as acute inflammatory processes are believed to play a role in reperfusion injury and tissue repair in the infarcted myocardium This is suggested by observational and experimental studies showing elevation of a number of inflammatory and cardiovascular proteins in the acute phase of M I5, correlating with infarct size, Scientific Reports | (2020) 10:18663. The objective of this study was to perform a large-scale proteomic analysis using a novel proximity extension assay (PEA) to evaluate the hypothesis that plasma concentrations of 157 inflammation- and cardiovascularassociated proteins correlate to infarct size and ejection fraction in the acute and chronic phase post-STEMI as assessed by cardiac magnetic resonance imaging (CMR)
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