Using Phase Synchrony Index for Improved Assessment of Consciousness in Ischemic Stroke Patients

Abstract

Accurate behavioral assessments of consciousness are crucial in guiding management as they provide diagnostic and prognostic information, but they are challenging since different clinical scales lead to varying results for the same patient. This paper aimed to investigate the phase synchrony index in differentiating the states of consciousness (wakefulness, somnolence, stupor, light coma, middle coma, and deep coma) in ischemic stroke. We evaluated whether the quantitative electroencephalography (EEG) measure, phase synchrony index of the left and right hemispheres, can facilitate the assessment of consciousness in stroke patients. This paper included 82 patients with ischemic stroke admitted for inpatient rehabilitation. The phase synchrony index of the left and right hemispheres was computed in the alpha band (8–12 Hz) and beta band (13–30 Hz), respectively. The associations between the phase synchrony index of the left and right hemispheres in two frequency bands with the clinical states, including the level of consciousness and the National Institutes of Health Stroke Scale score were analyzed. For further assessments of phase synchrony of the left and right hemispheres (PSI-LR), four local phase synchrony indexes in the beta band were also evaluated. The experiments result showed that PSI-LRs in the beta band correlated significantly with the level of consciousness of ischemic stroke patient and the National Institutes of Health Stroke Scale score, and they can identify the impaired consciousness in ischemic stroke patients with an accuracy of 84.15%. Compared with local phase synchrony, the phase synchrony index of channel FP1 and channel FP2 exhibited a more significant correlation with the level of consciousness than the other three local phase synchrony measures. These results suggest that the novel quantitative EEG measure, PSI-LR provides a new objective way to assess the level of consciousness in ischemic stroke patients.