Abstract
As a transcription factor, megakaryoblastic leukemia 1 (MKL1) binds with serum response factor (SRF) to regulate targeted genes expression. Therefore, it involved in various cellular processes, suc...
Highlights
Clustered regularly interspaced palindromic repeat (CRISPR) is firstly discovered in bacteria and considered as an adaptive immune system to degrade exogenous DNA [1]
According to the degradation modes of exogenous genetic material, CRISPR was classified to three systems [2]
In order to eliminate the effect, it usually uses D10A (Cas9 Nickase) with pairedguide RNA that target at DNA positive and negative strands to cut off two nicks
Summary
This is the unedited version of the article as it appeared upon acceptance by the. A final edited version of the article in the journal format will be made available soon. C As a service to authors and researchers we publish this version of the accepted manuscript (AM) as soon as possible after acceptance. Copyediting, typesetting, and review of the resulting proof will be undertaken on this manuscript before final. A publication of the Version of Record (VoR). 2. College of life science and healthy, Wuhan University of Science and Technology,. Wuhan University of Science and Technology, Wuhan, 430065, PR China. RETR # These authors contributed to this work
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