Abstract
Electron microscopic examination of B cells of pancreatic islets of the pancreas in dogs with normal (n=10) and impaired glucose tolerance (n=10) was performed. Ultrastructural features of the organization of insulin cells associated with an increased requirement of the hormone in the body with the latent form of diabetes mellitus are established. In B cells, signs of functional tension due to unregulated secretion, manifested by the expansion of endoplasmic reticulum cisterns, Golgi complex hypertrophy, an increase in the number of immature secretory granules and vacuoles in the cytoplasm are revealed in B cells.
Highlights
МЕТОДИКИ ИССЛЕДОВАНИЯФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава России, г
Electron microscopic examination of B cells of pancreatic islets of the pancreas in dogs with normal (n=10) and impaired glucose tolerance (n=10) was performed
Ultrastructural features of the organization of insulin cells associated with an increased requirement of the hormone in the body with the latent form of diabetes mellitus are established
Summary
ФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава России, г. В результате проведенного электронно-микроскопического исследования В-клеток панкреатических островков поджелудочной железы у собак с нормальной (n=10) и нарушенной (n=10) толерантностью к глюкозе, установлены ультраструктурные особенности организации инсулиноцитов, связанные с повышенной потребностью гормона в организме при латентной форме сахарного диабета. Electron microscopic examination of B cells of pancreatic islets of the pancreas in dogs with normal (n=10) and impaired glucose tolerance (n=10) was performed. Ultrastructural features of the organization of insulin cells associated with an increased requirement of the hormone in the body with the latent form of diabetes mellitus are established. В большинстве случаев исследования панкреатических островков собак проводятся с использованием иммуноцитохимических и гистологических методов. Цель исследования – в экспериментальных условиях выявить ультраструктурные особенности организации В-клеток панкреатического островка у животных с нормальной и нарушенной толерантностью к глюкозе
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