Abstract
The study aimed to determine the effect of S. cerevisiae and L. acidophilus as probiotic against S. typhimurium isolated from poultry, for this purpose (50) fecal samples were collected from poultry to isolated S. typhimurium, while fermented milk used for isolation of Lactobacillus acidophilus. Results of current study showed that S. typhimurium isolated in rate of 6%. In-Vivo adhesion Index test showed high ability of L. acidophilus to adhesion on rat intestine endothelium in compare with Saccharomyces cerevisiae .The inhibitory zone occurred by S.cerevisiae filtrate, L. acidophilus filtrate, (S .cerevisiae and L. acidophilus mixture) filtrate were (10, 16, 19 mm) respectively. The results of experimental study showed that high activity of (S.cerevisiae and L. acidophilus mixture) filtrate in protect experimental animals. Main pathological changes occurred by S.typhimurium were infiltration of inflammatory cells.
Highlights
Antibiotics are less effective against several bacterial pathogenic microbes, likeSalmonella strains, because of antibioticresistant bacteria so there is need for methods of preventing and treating infections caused by enteric pathogenic bacteria [1]
Studies have indicated that Saccharomyces cerevisiae can be used in the prevention and treatment of bacterial infectious diseases, including Paratyphoid, typhoid and nontyphoidal Salmonella [3]. [16] mention when chicks were given Salmonella spp at104 cfu/chick and were treated with 10 kinds of Lactobacillus at 108 cfu/chick, the results indicate that Lactobacillus can decrease the cecal Salmonella counts, decrease the mortality of dieased in chicks and booster the balance of intestinal flora
Isolation of L. acidophilus : L. acidophilus isolated on milk on Deman Regosa Sharp Broth (MRS) media, the early diagnosis depend on transparent zone round colony, negative to test
Summary
Antibiotics are less effective against several bacterial pathogenic microbes , likeSalmonella strains, because of antibioticresistant bacteria so there is need for methods of preventing and treating infections caused by enteric pathogenic bacteria [1]. Antibiotics are less effective against several bacterial pathogenic microbes , like. Lactobacillus and Bifidobacterium Species are the most commonly probiotics used for treatment the infectious diseases, including travellers’ diarrhoeas and antibiotic-associated. Probiotic defined by Schaafsma and Guraner as a microorganism that have good effects on human and animal health [5], while [6] defined probiotic as any production contain diagnostic microorganisms in adequate number which have ability to change numbers and types of microflora in the body. Main characters of microorganisms that using as probiotic are: not has pathogenic or toxic effects, able to grow and multiply in the intestine, resistant to bile duct product, constant genetically and storage [7]
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