Abstract
Inherited cardiomyopathies such as hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) have a high population prevalence of 1 in 500 and 1 in 250 individuals, respectively, in the US and Europe. Disease-related HCM and DCM effects range enormously from being asymptomatic to leading to heart failure and a need for heart transplantation. HCM is characterized by left ventricular (LV) hypertrophy, typically with increased calcium sensitivity of thin filament activation, while DCM exhibits LV dilatation and reduced calcium sensitivity.
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