Abstract
Background To predict the active components and potential targets of traditional Chinese medicine and to determine the mechanism behind the curative effect of traditional Chinese medicine, a multitargeted method was used. Jingzhi Guanxin prescriptions expressed a high efficacy for coronary heart disease (CHD) patients of which essential oils from Chuanxiong and Jiangxiang were confirmed to be the most important effective substance. However, the interaction between the active components and the targets for the treatment of CHD has not been clearly explained in previous studies. Materials and Methods Genes associated with the disease and the treatment strategy were searched from the electronic database and analyzed by Cytoscape (version 3.2.1). Protein-protein interaction network diagram of CHD with Jiangxiang and Chuanxiong essential oils was constructed by Cytoscape. Pathway functional enrichment analysis was executed by clusterProfiler package in R platform. Results 121 ingredients of Chuanxiong and Jiangxiang essential oils were analyzed, and 393 target genes of the compositions and 912 CHD-related genes were retrieved. 15 coexpression genes were selected, including UGT1A1, DPP4, RXRA, ADH1A, RXRG, UGT1A3, PPARA, TRPC3, CYP1A1, ABCC2, AHR, and ADRA2A. The crucial pathways of occurrence and treatment molecular mechanism of CHD were analyzed, including retinoic acid metabolic process, flavonoid metabolic process, response to xenobiotic stimulus, cellular response to xenobiotic stimulus, cellular response to steroid hormone stimulus, retinoid binding, retinoic acid binding, and monocarboxylic acid binding. Finally, we elucidate the underlying role and mechanism behind these genes in the pathogenesis and treatment of CHD. Conclusions Generally speaking, the nodes in subnetwork affect the pathological process of CHD, thus indicating the mechanism of Jingzhi Guanxin prescriptions containing Chuanxiong and Jiangxiang essential oils in the treatment of CHD.
Highlights
To predict the active components and potential targets of traditional Chinese medicine and to determine the mechanism behind the curative effect of traditional Chinese medicine, a multitargeted method was used
The potential molecular mechanism of CHD is unclear. erefore, there is an urgent need for indepth research and improvement of the treatment of CHD, in order to achieve the purpose of reducing the health and economic burden of patients with coronary heart disease
Materials and Methods e technical strategy of this research is shown in Figure 1. e research strategy was based on network pharmacology of deciphering key pharmacological pathways involved in Chuanxiong and Jiangxiang essential oils acting on CHD
Summary
Cardiovascular diseases (CVD) cause more than 17.3 million deaths per year with an estimated mortality increase to 23.6 million by 2030 [1, 2]. In Jingzhi Guanxin prescriptions, Chuanxiong and Jiangxiang essential oils are the most important material basis for promoting blood circulation and removing blood stasis [16, 17]. Our research group had carried out a massive systemic research of the essential oils On this basis, the related genes of CHD and essential oils were retrieved, and their biological functions were analyzed in order to further clarify the molecular mechanism of the essential oils in the treatment of CHD and to provide a reference for the clinical application of these essential oils and for further drug development. E research strategy was based on network pharmacology of deciphering key pharmacological pathways involved in Chuanxiong and Jiangxiang essential oils acting on CHD Materials and Methods e technical strategy of this research is shown in Figure 1. e research strategy was based on network pharmacology of deciphering key pharmacological pathways involved in Chuanxiong and Jiangxiang essential oils acting on CHD
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