Abstract
Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals. FMD virus (FMDV) shows a strong tropism for epithelial cells, and FMD is characterised by cell lysis and the development of vesicular lesions in certain epithelial tissues (for example, the tongue). By contrast, other epithelial tissues do not develop lesions, despite being sites of viral replication (for example, the dorsal soft palate). The reasons for this difference are poorly understood, but hypotheses are difficult to test experimentally. In order to identify the factors which drive cell lysis, and consequently determine the development of lesions, we developed a partial differential equation model of FMDV infection in bovine epithelial tissues and used it to explore a range of hypotheses about epithelium structure which could be driving differences in lytic behaviour observed in different tissues. Our results demonstrate that, based on current parameter estimates, epithelial tissue thickness and cell layer structure are unlikely to be determinants of FMDV-induced cell lysis. However, differences in receptor distribution or viral replication amongst cell layers could influence the development of lesions, but only if viral replication rates are much lower than current estimates.
Highlights
Foot-and-mouth disease (FMD) is one of the most infectious diseases of cloven-hoofed animals [1]
Given the lack of information on mechanism(s) involved in FMD virus (FMDV)-induced cell death [10], this study focuses on the events of cell lysis in general, rather than distinguishing between apoptosis and necrosis as the type of cell death preceding it
A step when investigating the dynamics of FMDV in epithelial tissues, would be to incorporate effects of the host immune response, for example, the antiviral action of interferon (IFN) or lymphocytes
Summary
Foot-and-mouth disease (FMD) is one of the most infectious diseases of cloven-hoofed animals [1]. Domestic and wildlife species are susceptible to infection by FMD virus (FMDV), including cattle, swine, sheep, deer, bison and antelope [2]. FMD is of significant worldwide socio-economic importance [1, 3, 4], because it can cause substantially reduced productivity in domestic.
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