Abstract
Biochemistry Pseudokinases are structurally similar to kinases but lack catalytic activity. Instead, pseudokinases often promote protein degradation by acting as scaffolds for ubiquitin ligases and their substrates. The pseudokinases TRIB1 and TRIB2 are implicated in leukemia and other cancers. Jamieson et al. and Foulkes et al. found that these proteins bound to clinically approved kinase inhibitors, which induced structural changes that led to their degradation upon interacting with ubiquitin ligases. Thus, these drugs might be repurposed to block the function of TRIBs in cancer patients. Sci. Signal. 11 , eaau0597, eaat7951 (2018).
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