Using Gabapentin to Treat Chronic Cough: A Review of Literature

Abstract

Chronic cough is a multifactorial symptom, and a legitimate medical concern, that often requires further investigation if resolution is not attained with initial therapeutic options. Gabapentin, an anticonvulsant used for a myriad of disease states, is suggested to have a positive effect on chronic cough. Pertinent literature was searched for, and critically appraised in order to determine the potential value of gabapentin in the treatment of chronic cough. Findings from salient literature demonstrate a decrease in both frequency and severity of chronic cough as primary endpoints. However, discontinuation of gabapentin precipitated a return of symptoms towards baseline values, which may suggest that sustained use is required to maintain such benefits. It is felt that, in light of recent literature, the use of gabapentin as an off-label treatment for chronic cough, refractory to typical treatment regimens, may be a viable option for select patients.