Abstract
All human genes have undergone hundreds of millions of years of evolution to have today’s sequences and associated functions. At the same time, ligands and receptors have also undergone co-evolution. Evolutionary methods can be used to find ligands and receptors that have not yet been discovered, leading to new clinical diagnoses and treatments. This talk will deal with: 1. From the perspective of homologous genes and paralogous genes, the co-evolution of the glycoprotein hormone family, including FSH, LH, TSH, and hCG together with their receptors. 2. Create clinically useful long-acting FSH based on the evolutionary approach. 3. Use the evolution method to find five orphan LGR receptors, followed by the identification of receptors for the ligands, relaxin and INSL3, as well as the ligand for LGR4. 4. Use evolutionary methods to discover a new human placental hormone (placensin) and a new gonadal hormone in fish (gonacin), both with important metabolic functions. 5. Does the chicken or the egg come first during evolution? Which came first, the ligand or the receptor?
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