Abstract
BackgroundExtreme delta brush (EDB) is considered a potential marker for anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis. The brain regions involved in EDB are unclear.Case presentationA 16-year-old woman with anti-NMDAR encephalitis who was experiencing psychosis was admitted. Electroencephalography (EEG) and magnetoencephalography (MEG) were used to analyze EDB in the patient. EDB on EEG could be disturbed by opening and closing the eyes, by occipital alpha rhythms and by sleep-wake cycles. The MEG results showed beta activity originating from bilateral superior parietal lobes. However, the delta wave originated from bilateral superior temporal gyri, the right middle temporal gyrus, the right inferior frontal gyrus, and the left inferior parietal lobe.ConclusionsDelta wave and beta activity might originate from different brain regions. Beta activity might be transmitted forward to the frontotemporal lobe and superimposed with delta activity to form EDB on EEG.
Highlights
Extreme delta brush (EDB) is considered a potential marker for anti-N-methyl-d-aspartate receptor encephalitis
Delta wave and beta activity might originate from different brain regions
Anti-N-methyl-d-aspartate receptor encephalitis is an autoimmune disease associated with serum and/or cerebral spinal fluid (CSF) antibodies against functional NMDAR [1, 2]
Summary
Delta wave and beta activity might originate from different brain regions. Beta activity might be transmitted forward to the frontotemporal lobe and superimposed with delta activity to form EDB on EEG.
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