Using Cytoprotective Features of Succinic Acid During the Rehabilitation of the Patients with Previous Acute Myocardial Infarction Complicated with Decompensated Heart Failure

Abstract

Aim: To improve treatment effectiveness for patients with previous myocardial infarction (MI) while studying clinical pathogenetic features of decompensated heart failure (HF) in the postinfarction period with the focus of using succinic acid. Materials and Methods: The work is based on the results of an examination of 60 patients with previous MI, who got registered decompensated II А-B CHF. The patients with previous STEMI complicated by decompensated HF were divided into groups: the I group included the patients with previous STEMI, who were getting standard treatment according to the guidelines of the MoH of Ukraine (beta-blockers, ACE inhibitors, dual antiplatelet therapy (acetylsalicylic acid+clopidogrel), nitrates, statins) (n=30); the II group included the patients with previous STEMI, who were getting succinic acid into the therapy complex beside the standard treatment. Results: We determined insignificant improvements in such symptoms, as angina, dyspnea, dizziness, and tiredness in the group of patients receiving standard treatment. Herewith using succinic acid reduced clinical signs of inadequate response to physical exercise significantly. Disregarding the one-sidedness of the probable dynamics of the aforementioned 6MWD characteristics, the positive dynamic was less significant in the case of standard treatment. all examined groups presented positive dynamics concerning decreasing the number of points in the patients with decompensated HF after STEMI during the therapy according to Borg’s scale. Conclusions: The use of succinic acid for patients with decompensated heart failure that occurred after STEMI is accompanied by positive clinical effects, and antiischemic and cytoprotective influence.