Abstract
Stimulant drugs, including novel psychoactive substances (NPS, formerly “legal highs”) have addictive potential which their users may not realize. Stimulants elevate extracellular dopamine (DA) by inducing DA efflux via the dopamine transporter (DAT) and inhibition of DA reuptake. In this work we aim to assess DAT responses to stimulant NPS by means of in vitro, in vivo and in silico approaches. We compared how NPS bind to rat DAT, using autoradiography assessment of [125I]RTI-121 displacement in rat striatal sections.
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