Abstract
Chronic kidney disease (CKD) is a public health issue and is associated with high morbidity and mortality. How to identify the high-risk CKD patients is very important to improve the long-term outcome. CHADS2 and CHA2DS2-VASc scores are clinically useful scores to evaluate the risk of stroke in patients with atrial fibrillation. However, there was no literature discussing about the usefulness of CHADS2 and CHA2DS2-VASc scores for cardiovascular (CV) and all-cause mortality prediction in CKD patients. This longitudinal study enrolled 437 patients with CKD. CHADS2 and CHA2DS2-VASc scores were calculated for each patient. CV and all-cause mortality data were collected for long-term outcome prediction. The median follow-up to mortality was 91 (25th–75th percentile: 59–101) months. There were 66 CV mortality and 165 all-cause mortality. In addition to age and heart rate, CHADS2 and CHA2DS2-VASc scores (both P value < 0.001) were significant predictors of CV and all-cause mortality in the multivariate analysis. Besides, in direct comparison of multivariate model, basic model + CHA2DS2-VASc score had a better additive predictive value for all-cause mortality than basic model + CHADS2 score (P = 0.031). In conclusion, our study showed both of CHADS2 and CHA2DS2-VASc scores were significant predictors for long-term CV and all-cause mortality in CKD patients and CHA2DS2-VASc score had a better predictive value than CHADS2 score for all-cause mortality in direct comparison of multivariate model. Therefore, using CHADS2 and CHA2DS2-VASc scores to screen CKD patients may be helpful in identifying the high-risk group with increased mortality.
Highlights
Chronic kidney disease (CKD) is a public health issue and is associated with high morbidity and mortality
After adding CHADS2 score and CHA2DS2-VASc score into the basic model respectively, we found both of basic model + CHADS2 score and basic model + CHA2DS2-VASC score had a better predictive value for CV mortality than basic model itself
After adding CHADS2 score and CHA2DS2-VASc score into the basic model respectively, we found both of basic model + CHADS2 score and basic model + CHA2DS2-VASc score had a better predictive value for all-cause mortality than basic model itself
Summary
Chronic kidney disease (CKD) is a public health issue and is associated with high morbidity and mortality. There was no literature discussing about the usefulness of CHADS2 and CHA2DS2-VASc scores for cardiovascular (CV) and all-cause mortality prediction in CKD patients. This longitudinal study enrolled 437 patients with CKD. Our study showed both of CHADS2 and CHA2DS2VASc scores were significant predictors for long-term CV and all-cause mortality in CKD patients and CHA2DS2-VASc score had a better predictive value than CHADS2 score for all-cause mortality in direct comparison of multivariate model. There was no literature discussing about the usefulness of CHADS2 and CHA2DS2-VASc scores for CV and all-cause mortality prediction in the patients with CKD.
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