Abstract
The biggest challenge for psychiatry today is the need to reveal and verify the essential pathologies of psychiatric syndromes, including discovering relevant molecular, synaptic, and circuit formulations of biologically based psychiatric diseases. Any demonstrated pathology that reflects the biology of a facet or characterizes a subgroup of a psychiatric syndrome would be an important target. Medical scientists must have asked this same question in the early 1900s when they were grasping for modern medicine handles on illness manifestations such as fever and dropsy (morbid edema).
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