Abstract
The proper functioning of multicellular systems often requires a high degree of coordination among the behaviors of individual cells. Such coordination arises from the ability of cells to communicate with each other. This communication is mediated by both mechanical and biochemical signals (1–3). Among the biochemical signals that can drive this coordination, extracellular ligands are often implicated as mechanisms for long-range coordination (4). However, in several biological contexts, most notably gametogenesis, cell-cell communication is ensured by the fact that cells remain physically connected via inter-cellular bridges (ICBs).
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