Using automated patch clamp for high throughput characterization of sodium and potassium channels in human induced pluripotent stem cell derived sensory neurons

Abstract

Dorsal root ganglion (DRG) neurons transfer sensory signals from the peripheral to the central nervous system. Understanding the electrophysiological properties of DRG neurons has a significant application for pain research and potential drug development. Given the limited availability of human DRG neurons, the development of human induced pluripotent stem cell (hiPSC)-derived sensory neurons (SNs) that contain DRG neuron electrophysiological properties provides a promising way to do in vitro pain research.