Abstract
Time-domain diffuse correlation spectroscopy (TD-DCS) has been recently proposed to improve detection of deep blood flow dynamics in a biological tissue, such as human brain. To obtain a high sensitive measurement, several experimental parameters such as the source-detector (SD) distance, gate opening time, and width need to be considered and optimized. We use a simulation approach to optimize these parameters based on Monte Carlo computations using a realistic human head model. Two cortical regions are investigated including the frontal and temporal lobes. SD distance ranging from 0 to 45mm, gate opening time from 400 to 1000ps, and gate width from 50 to 3000ps are considered. The goal is to find out the optimal combinations of these parameters by which the higher contrast measurement on the cortical dynamics can be achieved. The simulations show that with an acceptable input power of light, the combinations of SD distance ranging from 0 to 15mm, gate opening time at 700 to 800ps, and gate width of 800ps are optimal for achieving higher contrast measurement on the cortical dynamics. The simulation approach and results are helpful for the optimization of TD-DCS experimental design focused on brain functional detection.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
