Abstract
Objectives: The purpose of this study was to determine whether a correlation exists between a panel of immunohistochemical stains (consisting of estrogen receptor (ER), progesterone receptor (PR) and wild type p53 (p53)) and nodal status in women with endometrioid endometrial cancer. Methods: Three hundred forty-three women underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, bilateral pelvic and para-aortic lymph node dissection performed. All tumors were stained for ER, PR and p53. This panel was compared to the patient’s nodal status and other clinic-pathologic factors. All data was collected from the patients’ charts. Results: One hundred eight patients had grade 1 tumors (83.3% node negative), one hundred forty three had grade 2 (86.6% node negative), and seventy had grade 3 (74.3% node negative). One hundred thirty six patients (39.6%) had tumors that were positive for ER, PR and negative for p53. Twenty eight patients (8.1%) had tumors that were negative for ER, PR and positive for p53. One hundred seventy nine patients (52.1%) had tumors that had mixed staining. Only 6 (4.4%) patients with ER+, PR+, p53– tumors had positive node nodes (P = 0.005). None of the sixty patients with grade 1 tumors that stained ER+, PR+, p53– had positive nodes found. Conclusion: In women with grade 1 disease, no positive nodes were found if the tumors stained positively for ER and PR and negatively for p53. Further studies will look at staining in diagnostic biopsies specimens and their correlation with nodal status.
Highlights
Endometrial cancer is the most common gynecological cancer in the western world
One hundred thirty six patients (39.6%) had tumors that were positive for estrogen receptor (ER), PR and negative for p53
Twenty eight patients (8.1%) had tumors that were negative for ER, PR and positive for p53
Summary
Endometrial cancer is the most common gynecological cancer in the western world. It is estimated that 2.5% of women born today in the United States will be diagnosed with cancer of the endometrium [1], this means that 1 out of 40 women will be affected. It was predicted that in the United States in 2009 there were 42,160 new cases and 7780 resulting deaths [2]. Type 1 occurs in 70% - 80% of cases being preceded by hyperplastic endometrium, occurring at younger ages. The appearance of estrogen and progesterone receptors is correlated with a favorable prognosis [3]. Type 2 which takes place at advanced ages and accompanied usually with estrogen and progesterone receptor negativity is typically linked to more aggressive types and poorer prognosis
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
