Abstract
Aim:To determine the utility of TNF-α receptor (TNFR1) as a biomarker for the presence of aneurysms in patients with acute subarachnoid hemorrhage (SAH).Patient & methods:This is a prospective study in patients with acute spontaneous SAH. Arterial blood from catheter near aneurysm and peripheral venous blood samples are collected. TNFR1 levels were analyzed in patients with and without aneurysm.Results:80 patients were included, 58 were analyzed. 41 patients (70.7%) had an aneurysm. Venous TNFR1 levels >1658 pg/ml had 46.3% sensitivity and 94.1% specificity for aneurysms presence. TNFR1 >1658 pg/ml was also an independent predictor for its presence (odds ratio = 12.03 [1.13–128.16]; p = 0.039).Conclusion:High levels of TNFR1 in peripheral venous blood are associated with the presence of aneurysm in patients with acute SAH.
Highlights
TNF-α is a pro-inflammatory biomarker related to aneurysm growth and rupture
Due to its relationship with aneurysm formation and the possibility of detecting elevated values of this receptor in peripheral blood, TNFR1 could be used as a blood biomarker to predict the presence of intracranial aneurysms
Venous levels of TNFR1 were higher than arterial, making easy to use its determination as a screening method for the presence of aneurysms in patients with acute subarachnoid hemorrhage
Summary
To determine the utility of TNF-α receptor (TNFR1) as a biomarker for the presence of aneurysms in patients with acute subarachnoid hemorrhage (SAH). The purpose of this study is to determine cut-off values of TNFR1 in peripheral venous and in arterial blood collected near aneurysm via endovascular catheter, that might be indicative of the presence of aneurysm in patients with SAH in the acute phase
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