Abstract
In order to establish an alternative means for monitoring serum theophylline concentrations in neonates, the reliability of salivary theophylline concentrations was investigated. Eight premature neonates with apnea of prematurity were studied. Neonates received between 1.25 and 2.5 mg/kg of intravenous aminophylline every 12 h. Simultaneous samples of blood (0.25 ml) and unstimulated saliva (0.25-0.50 ml) were obtained 4 and 8 h after drug administration. Serum and salivary theophylline concentrations statistically correlated (r = 0.98, p less than 0.01). The mean serum/saliva ratio was 1.02 +/- 0.09, with an 8.9% interpatient variation. Serum theophylline concentrations can be predicted from the equation: serum concentration = 1.069 x saliva concentration - 0.193. The data suggest that theophylline serum and saliva concentrations in the apneic neonate are approximately equal. Salivary theophylline concentrations may be clinically useful when serum is not readily available.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callSimilar Papers
More From: Therapeutic drug monitoring
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
