Abstract
OBJECTIVE: Osteoarthritis (OA) is an age-related disease that occurs in various joints due to mechanical stress. Inflammation occurs at synovial membrane in early stage, and cartilage wears and joint function breaks as it progresses. In this study, we evaluated the usefulness of the mechanical stress loaded OA model in cultured human synovial sarcoma cell line by using the anti-inflammatory agents which commonly used in Japan to OA clinical treatment.
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