Abstract

Background. Sweat is an aggravating factor in atopic dermatitis (AD), regardless of age. Sweat allergy may be involved in AD aggravated by sweating. Objective. We investigated whether sweat exacerbates adult AD symptoms and examined the extent of sweat allergy's involvement. Method. We asked 34 AD patients (17 men, 17 women; mean age: 27.8 years) to record the extent to which sweat aggravated their symptoms on a 10-point numerical scale. Participant responses were compared with histamine release tests (HRT). Furthermore, 24 of the patients received instructions on methods of sweat management, and their outcomes were evaluated on a 10-point scale. Results. Sweat HRT results were class ≥ 2 in 13 patients, but HRT results were not correlated with the patients' self-assessments of symptom aggravation by sweat. One month after receiving sweat management instructions, a low mean score of 4.6 was obtained regarding whether active sweating was good, but a high mean score of 7.0 was obtained in response to whether the sweat management instructions had been helpful. Conclusion. Our investigation showed that patients' negative impressions of sweat might derive from crude personal experiences that are typically linked to sweating. Sweat management for patients with adult atopic dermatitis was extremely useful regardless of sweat allergy.

Highlights

  • Atopic dermatitis (AD) is a chronic relapsing eczematous skin disease characterized by pruritus and inflammation and is accompanied by cutaneous physiological dysfunction [1]

  • The histamine release induced by semipurified sweat antigen is mediated by specific immunoglobulin E (IgE) [7, 8]

  • We investigated whether sweat plays a role in exacerbating adult atopic dermatitis (AD) symptoms and examined the extent to which sweat allergy is involved

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Summary

Introduction

Atopic dermatitis (AD) is a chronic relapsing eczematous skin disease characterized by pruritus and inflammation and is accompanied by cutaneous physiological dysfunction [1]. Semipurified sweat antigen from normal adults induced histamine release from the basophils of 77% of patients with AD and 66% of patients with cholinergic urticaria in Japan [7, 8]. Sweat is an aggravating factor in atopic dermatitis (AD), regardless of age. We investigated whether sweat exacerbates adult AD symptoms and examined the extent of sweat allergy’s involvement. We asked 34 AD patients (17 men, 17 women; mean age: 27.8 years) to record the extent to which sweat aggravated their symptoms on a 10-point numerical scale. 24 of the patients received instructions on methods of sweat management, and their outcomes were evaluated on a 10-point scale. Sweat management for patients with adult atopic dermatitis was extremely useful regardless of sweat allergy

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