Abstract
Purpose:It is difficult to make a distinction between lower urinary tract infection(UTI) and acute pyelonephritis(APN) during the acute phase of febrile UTI due to nonspecific clinical symptoms and laboratory findings, especially among young children. We measured the serum procalcitonin(PCT) in children with UTI to distinguish between acute pyelonephritis and lower UTI, and to determine the accuracy of PCT measurement compared with other inflammatory markers. Methods:Serum samples were taken from children who admitted with unexplained fever or were suspected of having UTI. 51 children(mean 12.2±11.4 months) were enrolled in this study. Leukocyte counts, erythrocyte sedimentation rates(ESR) and C-reactive protein(CRP) were also measured. Renal parenchymal involvement was assessed by 99mTc DMSA scintigraphy in the first 7 days after admission. PCT was measured by immunoluminometric assay. Results:PCT values were significantly correlated with the presence of renal defects in children with UTI(n=16)(5.06±12.97 µg/L, P
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