Abstract
BackgroundThis cross-sectional analysis evaluated whether determination of E-selectin concentrations could identify deterioration of cardiometabolic risk profile or subclinical atherosclerosis in individuals at low-to-moderate risk included in The Brazilian Longitudinal Study of Adult Health—ELSA-Brasil.MethodsA sample of 984 individuals from ELSA-Brasil (35–54 years) without cardiovascular disease or diabetes was stratified according to E-selectin tertiles. Traditional risk factors, inflammatory markers and categories of coronary artery calcium (CAC) scores were evaluated across the tertiles by ANOVA or Chi-squared test. In linear regression models, associations of E-selectin levels with insulin resistance index, adjusted for age, sex and adiposity were tested.ResultsThe mean age of the participants was 45.8 (SD 4.9) years and 55 % were women. Mean values of age, anthropometric data, biochemical variables and inflammatory status increased across E-selectin tertiles. Also, a gradual deterioration of the cardiometabolic profile was reflected by increments in frequencies (95 % CI) of BMI ≥ 25 kg/m2 [53.7 % (48.5–58.8), 61.0 % (56.1–66.5) and 64.2 % (59.0–69.4), p = 0.019], hypertension [18.0 % (14.1–22.8), 19.8 % (15.4–24.6) and 24.8 % (20.4–29.9), p = 0.048], pre-diabetes [62.5 % (57.4–68.3), 63.1 % (58.4–69.6) and 73.8 % (68.8–78.3), p = 0.003] and hypertriglyceridemia [22.4 % (17.9–27.2), 27.3 % (22.5–32.8) and 33.4 % (28.3–38.5), p = 0.013]. Insulinemia and HOMA-IR were independently associated with E-selectin concentration. A greater proportion of individuals with CAC scores different from zero was found in the third tertile when compared with the first and second tertiles (16.1 versus 11 %, p = 0.04, respectively).ConclusionsDirect associations of E-selectin with traditional risk factors slightly above their normal ranges, components of the metabolic syndrome, insulin resistance and presence of CAC suggest that this biomarker may indicate an initial atherogenic process.
Highlights
This cross-sectional analysis evaluated whether determination of E-selectin concentrations could iden‐ tify deterioration of cardiometabolic risk profile or subclinical atherosclerosis in individuals at low-to-moderate risk included in The Brazilian Longitudinal Study of Adult Health—ELSA-Brasil
The selectin family was shown to participate in this process [11] and has been associated with cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM) [7, 11, 12], but with the cardiometabolic profile among low-to-moderate risk individuals has been less investigated
The C-reactive protein (CRP) did not differ across E-selectin tertiles, inflammatory status changed significantly across these categories
Summary
This cross-sectional analysis evaluated whether determination of E-selectin concentrations could iden‐ tify deterioration of cardiometabolic risk profile or subclinical atherosclerosis in individuals at low-to-moderate risk included in The Brazilian Longitudinal Study of Adult Health—ELSA-Brasil. Metabolic disorders such as type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD) are major causes of death worldwide [1]. Low-grade inflammation and endothelial dysfunction are involved in the insulin resistance de Almeida‐Pititto et al Diabetol Metab Syndr (2016) 8:19 syndrome Both abnormalities are present in atherosclerosis and precede the development of T2DM [5, 6]. The selectin family was shown to participate in this process [11] and has been associated with CVD and T2DM [7, 11, 12], but with the cardiometabolic profile among low-to-moderate risk individuals has been less investigated
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
