Abstract
BackgroundTo investigate the link between carbamylated low-density lipoprotein (ca-LDL), atherogenic index of plasma (AIP), atherogenic coefficient (AC), Castelli’s risk indices I and II (CRI I and II) and subclinic atherosclerosis in psoriatic arthritis (PsA).MethodsThirty-ninepatients and 19 age, sex, body mass index matched healthy controls were included. Insulin resistance (IR) was assessed with homeostasis of model assessment-IR (HOMA-IR). Carotid intima-media thickness (CIMT) was measured at both common carotid arteries and mean CIMT was calculated.ResultsThe mean age was 49.50 ± 11.86 years and 64.1% were females in PsA group. In the PsA group, CIMT and HOMA-IR were significantly higher (p = 0.003, p = 0.043, respectively). AIP, AC, TG/HDL, CRI-1, CRI-2 and ca-LDL levels were similar between groups. In PsA group, CIMT was positively correlated with HOMA-IR, TG/HDL and AIP. Although ca-LDL was positively correlated with serum amyloid A (r = 0.744, p < 0.001), no correlation was detected between ca-LDL and CIMT (r = 0.215, p = 0.195). PsA patients with IR tended to have higher ca-LDL levels than patients without IR, but this difference lacked statistical significance (33.65 ± 26.94, 28.63 ± 28.06, respectively, p = 0.237).ConclusionsA significant increase in CIMT was seen in PsA patients without clinically evident cardiovascular disease or any traditional atherosclerosis risk factors. CIMT was correlated with HOMA-IR, TG/HDL and AIP.
Highlights
Psoriatic arthritis (PsA) is an inflammatory arthritis that can lead to significant joint damage and disability
In this study we aimed to investigate the link between carbamylated low-density lipoprotein (ca-LDL), atherogenic index of plasma (AIP), atherogenic coefficient (AC), CRI and subclinic atherosclerosis in patients with psoriatic arthritis (PsA)
In PsA group, carotid intima-media thickness (CIMT) was positively correlated with homeostasis model assessment (HOMA)-Insulin resistance (IR), TG/HDL and AIP, there was no correlation between caLDL, AC, CRI-1, CRI-2 and CIMT (Table 2)
Summary
Psoriatic arthritis (PsA) is an inflammatory arthritis that can lead to significant joint damage and disability. An increased morbidity risk for myocardial infarction, stroke and heart failure of 68, 22 and 31%, respectively, in patients with PsA was reported in that. Assessing clinical endpoints, such as myocardial infarction or stroke, in prospective cohort studies requires following large patients cohorts for extended periods of. Tecer et al Advances in Rheumatology (2019) 59:49 time Due to this limitation, surrogate endpoints such as imaging modalities of atherosclerosis or serum biomarkers vascular and metabolic function are commonly investigated to reveal the link between PsA and CVD [9]. Increased CIMT were reported in PsA patients without clinically evident cardiovascular disease or any traditional atherosclerosis risk factors [14]. To investigate the link between carbamylated low-density lipoprotein (ca-LDL), atherogenic index of plasma (AIP), atherogenic coefficient (AC), Castelli’s risk indices I and II (CRI I and II) and subclinic atherosclerosis in psoriatic arthritis (PsA)
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