Use Siphoviridae Bacteriophage as a Treatment for Mice Infected with MDR Pseudomonas aeruginosa and Histopathology Study

Abstract

The study was carried out to isolate, purify and quantification of bacteriophages against Multiple Drugs Resistance (MDR) P. aeruginosa, and using a bacteriophage as a treatment for mice experimentally. Four groups (Intraperitoneal injection group, local swab group, Positive group, and Negative group) of animals were tested for purpose of using lytic phages of Siphoviridae family as a treatment for MDRs P. aeruginosa isolated from patients suffering from moderate to severe burns wound infection. The current study presents evidence in murine models that animals can be successfully treated with specific bacteriophages that target these MDRs microbes.