Abstract
A s biology teachers, we are aware of the ever growing amount of information and new methods that we would like to incorporate into our classes. One area of particular growth has been in the field of DNA manipulations, or molecular biology. All of us want to share with our students these new and exciting techniques that are driving the revolution in biotechnology in addition to the fundamentals of population genetics, DNA structure, replication and mutations. We have developed a laboratory procedure that draws upon all of these topics and is appropriate for introductory level college biology courses (for majors and/or nonmajors), as well as advanced high school biology classes. Using the protocols described in this article, in two lab periods of two hours each, every student extracts his or her own DNA from a single hair follicle, uses polymerase chain reaction (PCR1) to amplify a polymorphic locus, electrophoreses the PCR products on an agarose gel, and visualizes the alleles to gener-
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